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protease inhibitor Definition

protease inhibitor

noun

a class of synthetic, antiviral drugs that limit or block the production of protease enzymes, which are essential in the reproductive cycle of the AIDS virus

protease inhibitor Usage Examples

Converse of object

  • call: The Federal Drug Agency approved the first of a potent new family of anti-HIV drugs called protease inhibitors.
  • take: This danger is increased if a person is taking a protease inhibitor as part of their therapy.
  • include: If your current failing combination includes a protease inhibitor you will have developed some resistance to PIs.
  • use: Four posters reported findings from studies evaluating PK parameters of two commonly used protease inhibitors and the nucleotide analog tenofovir in pregnancy.
  • contain: As well as phytoestrogens, soya contains protease inhibitors which have been shown to block cancer-causing protease enzymes.
  • receive: Hyperglycaemia New onset diabetes mellitus, hyperglycaemia, and exacerbation of existing diabetes mellitus have been reported in patients receiving protease inhibitors.

Converse of subject

  • cause: It's thought these complications are caused by protease inhibitors blocking the elimination of corticosteroids leading to higher concentrations in the blood.

Adjective modifier

  • ritonavir-boosted: Why are more people living with HIV in the UK starting therapy with a ritonavir-boosted protease inhibitor?
  • other: This will also be true for other protease inhibitors.
  • new: If you just switch to one new protease inhibitor as part of a triple combination, this may not be enough.
  • multiple: The new drug will be indicated for highly pre-treated adults with virus resistant to multiple protease inhibitors.
  • only: Nelfinavir is the only protease inhibitor which is not taken boosted with ritonavir.
  • common: The commonest protease inhibitor in the blood is alpha-1 antitrypsin and its role is to protect the tissues from protease attack.

Modifies a noun

  • tipranavir: Tipranavir licensed in Europe Boehringer Ingelheim's novel protease inhibitor tipranavir ( Aptivus ) received European approval on 25 October.
  • ritonavir: As the body processes them using the same mechanism, the protease inhibitor ritonavir increases levels of methamphetamine to possibly dangerous levels.
  • drug: They showed that giving two protease inhibitor drugs, indinavir and saquinavir, greatly reduced the growth of KS tumors in mice.
  • nelfinavir: The study looked at 41 patients new to HIV therapy in Philadelphia all on combos based on the protease inhibitor nelfinavir.
  • indinavir: Protease inhibitors Indinavir: indinavir is also associated with indirect ( unconjugated ) hyperbilirubinemia due to inhibition of UGT.

Preposition: in

  • blood: This has been done for many years by using ritonavir to boost the levels of other protease inhibitors in the blood.

Preposition: as

  • part: This danger is increased if a person is taking a protease inhibitor as part of their therapy.