- (idiomatic) Indicates enthusiastic agreement.
- Of course I'll go with you.
- (idiomatic) Acknowledges the validity of the associated phrase.
- Of course, there will be a few problems along the way.
- (idiomatic) Asserts that the associated phrase should not be argued, particularly if it is obvious or there is no choice in the matter.
- Of course I know that!
- You will, of course, surrender all your future rights to the property.
From literal meaning "of the ordinary course of events". Oldest attestation as "of course" from the 1540s, but previously used in the same sense as "by course" (then-spelled "bi cours", sic) since ca. 1300. (Source: Etymonline.com)