Louisville[lo̵̅o̅′ə vəl, lo̵̅o̅′ē vil]
city in N Ky., on the Ohio River: pop. 256,000
Origin of Louisvilleafter Louis XVI
The largest city of Kentucky, in the north-central part of the state on the Ohio River southwest of Cincinnati. Originally the site of a fort built by George Rogers Clark in 1778, it is now the center of a large metropolitan area and home to the Kentucky Derby.