- Lez is defined as a disrespectful slang term for a lesbian.
An example of lez is what an immature high school student would call two girls holding hands.
Webster's New World College Dictionary Copyright © 2010 by Wiley Publishing, Inc., Cleveland, Ohio.
Used by arrangement with John Wiley & Sons, Inc.
or lez·zienoun pl. lez·zes or lez·zies Offensive Slang
Origin: Shortening and alteration of lesbian.