- Lez is defined as a disrespectful slang term for a lesbian.
An example of lez is what an immature high school student would call two girls holding hands.
lez definition by Webster's New World
lez definition by American Heritage Dictionary
or lez·zienoun pl. lez·zes or lez·zies Offensive Slang
Used as a disparaging term for a lesbian.
Origin: Shortening and alteration of lesbian.