- Lez is defined as a disrespectful slang term for a lesbian.
An example of lez is what an immature high school student would call two girls holding hands.
nounpl. lez·zes or lez·zies Offensive Slang
Used as a disparaging term for a lesbian.
Origin of lezShortening and alteration of lesbian.
- (slang can be vulgar) Lesbian.
First syllable of lesbian.