The alkaloids fall into two chemical groups: (i) derivatives of isoquinoline, including papaverine, narcotine, gnoscopine (racemic narcotine), narceine, laudanosine, laudanine, cotarnine, hydrocotarnine (the last two do not occur in opium), and (2) derivatives of phenanthrene, including morphine, codeine, thebaine.
Its synthesis, and also that of laudanosine, C21H27N04, which is N-methyltetrahydropapaverine, was effected in 1909 by F.
Laudanine, C20H25N04, is very similar to laudanosine, differing in having three methoxy groups and one hydroxy instead of four methoxy.
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