The Buddha says: "Those indeed are conquerors who, as I have now, have conquered the intoxications (the mental intoxication arising from ignorance, sensuality or craving after future life).
The negative side, the qualities that have to be suppressed by the cultivation of the opposite virtues, are the Ten Bonds (Samyojanas), the Four Intoxications (Asava) and the Five Hindrances (Nivaranas).
The Four Intoxications are the mental intoxication arising respectively from (1) Bodily passions, (2) Becoming, (3) Delusion, (4) Ignorance.
And gladness springs up within him on his realizing that, and joy arises to him thus gladdened, and so rejoicing all his frame becomes at ease, and being thus at ease he is filled with a sense of peace, and in that peace his heart is stayed."9 To have realized the Truths, and traversed the Path; to have broken the Bonds, put an end to the Intoxications, and got rid of the Hindrances, is to have attained the ideal, the Fruit, as it is called, of Arahatship. One might fill columns with the praises, many of them among the most beautiful passages in Pali poetry and prose, lavished on this condition of mind, the state of the man made perfect according to the Buddhist faith.
Over and above the bacterial intoxications we have a very extreme degree of fatty degeneration, widely distributed throughout the tissues, which is produced by certain organic and inorganic poisons; it is seen especially in phosphorus and chloroform poisoning.