an enzyme that inactivates hyaluronic acid by breaking down its polymeric structure, thus promoting the diffusion of substances through tissues: found in sperm cells, certain venoms and bacteria, etc.
Origin:
< hyaluronic acid + -id(e) + -ase
See hyaluronidase in American Heritage Dictionary 4
noun
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.