In 1894 and 1895, Fischer, in a remarkable series of papers on the influence of molecular structure upon the action of the enzyme, showed that various species of yeast behave very differently towards solutions of sugars.
Fischer next suggested that enzymes can only hydrolyse those sugars which possess a molecular structure in harmony with their own, or to use his ingenious analogy, "the one may be said to fit into the other as a key fits into a lock."
Fischer found that the enzyme "invertase," which is present in yeast, attacks methyl-d-glucoside but not methyl-l-glucoside.
The remarkable discoveries of Fischer and Buchner to a great extent confirm Traube's views, and reconcile Liebig's and Pasteur's theories.
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