Preposition: of

• tissue: Grade 3 Full thickness skin loss involving damage or necrosis of subcutaneous tissue extending to, but not through the muscle.

• bone: Grade 4 4.1 4.2 Full thickness skin loss with destruction and necrosis of bone, tendon or joint capsule.

Converse of object

• induce: These drugs induce necrosis of the parasite but also produce unwanted side-effects in treated animals.

Adjective modifier

• avascular: Avascular necrosis means the death of the bone due to deprivation of its blood supply.

• papillary: Renal: Papillary necrosis which can lead to renal failure.

• aseptic: PITFALLS IN DIAGNOSIS Prolonged dislocation of the femoral head may increase the rate of aseptic necrosis.

• tubular: Acute renal failure with acute tubular necrosis may develop even in the absence of severe liver damage.

• pancreatic: Infection of pancreatic necrosis was the main risk factor for death.

• ischaemic: Loss of blood supply following trauma: will cause ischaemic necrosis.

Modifies a noun

• factor-alpha: A cytokine called tumor necrosis factor-alpha plays a key role in regulating the severity of an immune response.

• alpha: Tumor necrosis factor alpha also plays a pivotal part in inflammation.

• factor: There is a particular emphasis on the role of members of the tumor necrosis factor family.

• receptor: A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.

• virus: First isolation of infectious pancreatic necrosis virus from carp.

Noun used with modifier

• anti-tumour: The prevalence of patients with rheumatoid arthritis in the West Midlands fulfilling the BSR criteria for anti-tumour necrosis factor therapy: an out-patient study.

• pith: Pith necrosis symptoms developed on inoculated plants in 7 days. No symptoms developed on negative control plants.

• tumor: Bone invasion and tumor necrosis, features not reported before, were found in six cases each.

• tumor: There is a particular emphasis on the role of members of the tumor necrosis factor family.

• radiation: There is the risk of radiation necrosis of the skin.

• tissue: Speeding up the healing of wounds is likely to reduce complications such as infections and tissue necrosis.