mutation - use in sentences

Converse of object

• inherit: Not everyone who has inherited a genetic mutation for Gaucher disease from both parents has symptoms.

• attenuating: The attenuating mutation at residue 91 in VP3 is shown in cyan, and all suppressor mutations are shown in white.

• truncate: Milder disease was observed in some cases carrying missense mutations as compared with those carrying truncating mutations.

• induce: More recently, I have been involved in the detailed determination of gene function through induced mutation of the genes encoding renin.

Preposition: in

• exon: No point mutation in exons 20 to 24 and their flanking introns were found in any of the 35 patients.

• gene: A mutation in a patterning gene could give rise to a simple heart defect, not a full scale patterning defect.

Adjective modifier

• somatic: These genes are often screened for somatic mutations only in the region most likely to contain mutations.

• brca2: Comment: The clinical relevance of this paper is unclear, as no-one is currently proposing population screening for BRCA1 and BRCA2 mutations.

• genetic: However a gap remained between linking a genetic mutation to the outcome of the disease.

• brca1: That is, women with negative results for BRCA1 mutation are still at risk of cancer.

• missense: This project addresses how missense mutations are analyzed before an interpreted report is issued.

• deleterious: High frequency of cryptic deleterious mutations in Caenorhabditis elegans.

Modifies a noun

• assay: Negative results are available for a gene mutation assay in Salmonella.

• carrier: Should cancers in mutation carriers be managed differently from sporadic cases?

Noun used with modifier

• missense: Missense mutation analysis This project is investigating the application of bioinformatic tools to determine the pathogenicity of unclassified missense mutations.

• p53: The survival rate in the 24 patients with p53 mutation did not differ significantly from that in the 16 patients without p53 mutation.

• germline: Many members of Li-Fraumeni families have a germline mutation of the TP53 gene.

• frameshift: It was not able to induce point and frameshift mutations in haploid Saccharomyces cerevisiae cells.

• gene: Importantly, in rare families, a gene mutation has been shown to cause the abnormal build up of tau protein in the brain.

• mtdna: By contrast, a woman with a heteroplasmic mtDNA mutation, may transmit a variable amount of mutated mtDNA to her children.