Darien[dar′ē en′, der′-; also där yen′]
- wedge-shaped extension of the Caribbean, between N Colombia & E Panama
- Isthmus of Panama
A region of eastern Panama on the Gulf of Darién, a wide bay of the Caribbean Sea between eastern Panama and northwest Colombia. In 1513 Vasco Núñez de Balboa led an expedition across the Isthmus of Darién (now the Isthmus of Panama) and became the first European to reach the west coast of the Americas.