(Simulation Program with Integrated Circuit Emphasis) A program widely used to simulate the performance of analog electronic systems and mixed mode analog and digital systems. SPICE solves sets of non-linear differential equations in the frequency domain, steady state and time domain and can simulate the behavior of transistor and gate designs. Developed at the University of California at Berkeley in the mid-1970s, there are enhanced versions of SPICE provided by several software companies. PSpice is a version for personal computers such as DOS, Windows and Mac.