cisplatin Hear it!

cisplatin Definition

cis·platin (sis plat'n)

noun

a white, powdery drug, PtClHN, containing platinum, used to stop the growth of cancerous tumors, esp. in the ovary, testis, or bladder

Etymology: cis- + platin(um)

cisplatin Usage Examples

Converse of object

  • receive: The SmPC describes in some detail the hearing impairment in patients receiving cisplatin and notes that it is worse in children.
  • use: Studies were excluded if they used cisplatin and carboplatin in the same arm or used drugs not considered established cytotoxics.
  • include: Drugs that are often investigated in combination with radiotherapy include cisplatin, capecitabine and 5FU.
  • contain: Combinations containing cisplatin, cyclophosphamide and doxorubicin were studied in the 1980s and showed improved median progression-free survival.
  • base: Measurement of these adducts prior to therapy could be of value to improve cisplatin based cancer therapy.
  • call: Treatment In the 1970s, a breakthrough drug called cisplatin was developed that dramatically improved the outlook for men with advanced testicular cancer.

Preposition: for

cancer: Neoadjuvant cisplatin for advanced bladder cancer ( Cochrane Collaboration ) Abstract of a systematic review.

Preposition: as

chemotherapy: We evaluated the efficacy and toxicity of CPT-11 plus cisplatin as first-line chemotherapy in patients with advanced or recurrent cervical cancer.

Modifies a noun

  • chemotherapy: Navari RM: Comparison of intermittent versus continuous infusion metoclopramide in control of acute nausea induced by cisplatin chemotherapy.
  • therapy: Hearing loss as a result of cisplatin therapy may give rise to persistent or worsening symptoms.
  • combination: Until recently, the methotrexate, vinblastine, doxorubicin and cisplatin combination has been considered the standard for treating this disease.
  • infusion: Parameters of intravenous cisplatin infusion in cirrhotic patients are similar to those of patients from the historic control group.

Noun used with modifier

low-dose: Our previous study suggested that daily administration of low-dose cisplatin enhanced the efficacy of radiotherapy against primary oral squamous carcinoma.

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