At Strassburg began his intimacy with Caspar Schwenkfeld, a congenial spirit.
It is a striking example of the difficulty of getting people to use their own powers of investigation accurately, that this form of the doctrine of evolution should have held its ground so long; for it was thoroughly and completely exploded, not long after its enunciation, by Caspar Frederick Wolff, who in his Theoria generationis, published in 1759, placed the opposite theory of epigenesis upon the secure foundation of fact, from which it has never been displaced.
This point of view was further developed in the following century by Caspar Friedrich Wolff (Theorici generationis, 1759), who first followed the development of the members at the growing-point of the stem.
He was also called upon to do battle for his principle against men like Caspar Schwenkfeld (1490-1561) and Sebastian Franck (1500-1545), the latter of whom developed a system of pantheistic mysticism, and went so far in his opposition to the letter as to declare the whole of the historical element in Scripture to be but a mythical representation of eternal truth.
He ineffectually resisted the efforts of the Calvinists, led by Caspar Olevianus, to introduce the Presbyterian polity and discipline, which were established at Heidelberg in 1570, on the Genevan model.