He owed his escape from the violence of competitors and nobles, partly to the tact and undaunted bravery of his mother Maria de Molina, and partly to the loyalty of the citizens of Avila, who gave him refuge within their walls.
The city is built at the narrow end of the valley and at the foot of the Cerro de Avila, and stands from 2887 to 3442 ft.
Vasco Nunez was beheaded in 1517 by Pedrarias de Avila, who was sent out to supersede him.
He took up his residence in Avila, where he had built a convent; and here he resumed the common life of a friar, leaving his cell in October 1497 to visit, at Salamanca, the dying infante, Don Juan, and to comfort the sovereigns in their parental distress.
They often used to visit him at Avila, where in 1498, still in office as inquisitor-general, he held his last general assembly to complete his life's work.