The congenital immunodeficiency disorder, Bruton's agammaglobulinemia, also known as X-linked agammaglobulinemia, results in a decrease or absence of B lymphocytes and, therefore, a decreased ability to make antibodies.
Bruton's agammaglobulinemia is a disorder that is present at birth (congenital) and is characterized by low or completely absent levels of immunoglobulins in the bloodstream.
X-linked agammaglobulinemia is an inherited disease stemming from a defect on the X chromosome, consequently affecting more males than females.
Immunoglobulin heavy chain deletion, a form of agammaglobulinemia, is a genetic disorder in which part of the antibody molecule is absent.
Patients with Bruton's agammaglobulinemia must be given periodic infusions of pooled immunoglobulin from multiple donors.