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Addison's disease

The definition of Addison's disease, also called primary adrenal insufficiency, is when the adrenal glands do not produce enough cortisol and aldosterone.

Facts About Addison's Disease

  • Over time, the adrenal glands will shrink if they are not stimulated to make cortisol.
  • Functions of cortisol - Regulating blood pressure, maintaining cardiovascular function, maintaining glucose levels, supporting immune functions and regulating the body's inflammatory response.
  • Functions of aldosterone - Regulating sodium and potassium levels in the body, helping to maintain blood pressure.
  • Symptoms - Fatigue, loss of appetite, weight loss, muscle weakness, low blood pressure, salt cravings, nausea and darkening of the skin.
  • Causes - Any disease that causes the adrenal cortex to be destroyed or partially destroyed can cause Addison’s disease.
  • Diagnosis - The most common test for detecting Addison’s disease is the ACTH stimulation test.
  • Treatment - Replacing the hormones that your body needs that are not being made by the adrenal glands.
  • If left untreated, Addison’s disease can be fatal.
(noun)

An example of Addison's disease is damage to the adrenal glands caused by tuberculosis, cancer and chronic infection.

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See Addison's disease in Webster's New World College Dictionary

a disease caused by failure of the adrenal glands: it is characterized by anemia, weakness, low blood pressure, and brownish discoloration of the skin

Origin: after T. Addison (1793-1860), Eng physician who identified it

See Addison's disease in American Heritage Dictionary 4

noun
A disease caused by partial or total failure of adrenocortical function, which is characterized by a bronzelike pigmentation of the skin and mucous membranes, anemia, weakness, and low blood pressure.

Origin:

Origin: After Thomas Addison (1793-1860), British physician

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